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Because serum alanine aminotransferase (ALT) levels have been reported to predict the histological course of NASH and because strict control of ALT is required to prevent the progression of NASH [13], the primary outcome of this study was a change in ALT levels

Nrf2 overexpression inhibited the Tat effects, reducing the intracellular ROS and increasing intracellular levels of GSH [28]

While FDA-approved GLP-1 RAs have transformed the treatment landscape for obesity and diabetes through their effects on appetite, glycemic control, and weight reduction, glutathione may offer complementary benefits by addressing the oxidative stress component of metabolic dysfunction

The relevance of this enzyme is illustrated by the fact that global SOD2 deficiency leads to neonatal death in mice (Huang et al., 1997)